Recurrence of Acute Lymphoblastic Leukemia with Bone Marrow Necrosis: A Case Report and Review of the Literature on the MRI Features of Bone Marrow Necrosis

Naonori Harada; Mitsutaka Nishimoto; Aya Ikemoto; Hiroshi Okamura; Shiro Koh; Satoru Nanno; Yasuhiro Nakashima; Hideo Koh; Takahiko Nakane; Yuko Kuwae; Masahiko Ohsawa; Masayuki Hino; Hirohisa Nakamae

doi:10.2169/internalmedicine.5815-20

CASE REPORTS

Recurrence of Acute Lymphoblastic Leukemia with Bone Marrow Necrosis: A Case Report and Review of the Literature on the MRI Features of Bone Marrow Necrosis

Naonori Harada, Mitsutaka Nishimoto, Aya Ikemoto, Hiroshi Okamura, Shiro Koh, Satoru Nanno, Yasuhiro Nakashima, Hideo Koh, Takahiko Nakane, Yuko Kuwae, Masahiko Ohsawa, Masayuki Hino, Hirohisa Nakamae

著者情報

Naonori Harada
Department of Hematology, Graduate School of Medicine, Osaka City University, Japan
Mitsutaka Nishimoto
Department of Hematology, Graduate School of Medicine, Osaka City University, Japan
Aya Ikemoto
Department of Clinical Laboratory, Osaka City University Hospital, Japan
Hiroshi Okamura
Department of Hematology, Graduate School of Medicine, Osaka City University, Japan
Shiro Koh
Department of Hematology, Graduate School of Medicine, Osaka City University, Japan
Satoru Nanno
Department of Hematology, Graduate School of Medicine, Osaka City University, Japan
Yasuhiro Nakashima
Department of Hematology, Graduate School of Medicine, Osaka City University, Japan
Hideo Koh
Department of Hematology, Graduate School of Medicine, Osaka City University, Japan
Takahiko Nakane
Department of Hematology, Graduate School of Medicine, Osaka City University, Japan
Yuko Kuwae
Department of Diagnostic Pathology, Graduate School of Medicine, Osaka City University, Japan
Masahiko Ohsawa
Department of Diagnostic Pathology, Graduate School of Medicine, Osaka City University, Japan
Masayuki Hino
Department of Hematology, Graduate School of Medicine, Osaka City University, Japan
Hirohisa Nakamae
Department of Hematology, Graduate School of Medicine, Osaka City University, Japan

キーワード: bone marrow necrosis, bone marrow aspiration from the sternum, acute lymphoblastic leukemia, magnetic resonance imaging

ジャーナルオープンアクセス

2021 年 60 巻 7 号 p. 1083-1088

DOI https://doi.org/10.2169/internalmedicine.5815-20

Browse “Advance online publication” version

詳細

抄録

Bone marrow necrosis (BMN) is a rare but important complication of hematological malignancies. We report the case of a 52-year-old male patient with a recurrence of acute lymphoblastic leukemia (ALL) accompanied by BMN. After re-induction therapy, bone marrow aspiration (BMA) and biopsy from the iliac bone showed necrotic cells and eosinophilic debris, respectively. Magnetic resonance imaging (MRI) showed heterogeneous signals in the bilateral iliac bone, possibly reflecting various stages of BMN. BMA from the sternum eventually revealed the recurrence of ALL after a few weeks. Comprehensive assessments, including MRI and repeated bone marrow tests, are required when evaluating the underlying hematological malignancies of patients with BMN.

責任著者(Corresponding author)

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