Early Improvement of Non-islet Cell Tumor Hypoglycemia by Chemotherapy Using Lenvatinib in a Case with Type 2 Diabetes and Hepatocellular Carcinoma Producing Big IGF-II

Takuma Izutsu; Hiroyuki Ito; Izumi Fukuda; Hideki Tamura; Suzuko Matsumoto; Shinichi Antoku; Toshiko Mori; Hiroaki Goto

doi:10.2169/internalmedicine.5328-20

CASE REPORTS

Early Improvement of Non-islet Cell Tumor Hypoglycemia by Chemotherapy Using Lenvatinib in a Case with Type 2 Diabetes and Hepatocellular Carcinoma Producing Big IGF-II

Takuma Izutsu, Hiroyuki Ito, Izumi Fukuda, Hideki Tamura, Suzuko Matsumoto, Shinichi Antoku, Toshiko Mori, Hiroaki Goto

著者情報

Takuma Izutsu
Department of Diabetes, Metabolism and Kidney Disease, Edogawa Hospital, Japan
Hiroyuki Ito
Department of Diabetes, Metabolism and Kidney Disease, Edogawa Hospital, Japan
Izumi Fukuda
Department of Endocrinology, Diabetes and Metabolism, Graduate School of Medicine Nippon Medical School, Japan
Hideki Tamura
Department of Endocrinology, Diabetes and Metabolism, Graduate School of Medicine Nippon Medical School, Japan
Tamura Clinic, Japan
Suzuko Matsumoto
Department of Diabetes, Metabolism and Kidney Disease, Edogawa Hospital, Japan
Shinichi Antoku
Department of Diabetes, Metabolism and Kidney Disease, Edogawa Hospital, Japan
Toshiko Mori
Department of Diabetes, Metabolism and Kidney Disease, Edogawa Hospital, Japan
Hiroaki Goto
Department of Oncology and Hematology, Edogawa Hospital, Japan

キーワード: non-islet cell tumor hypoglycemia, hypoglycemia, hepatocellular carcinoma, IGF-II, lnevatinib

ジャーナルオープンアクセス

2021 年 60 巻 9 号 p. 1427-1432

DOI https://doi.org/10.2169/internalmedicine.5328-20

J-STAGE : internalmedicine 60 12 pp.1985-1985

Browse “Advance online publication” version

詳細

抄録

A 77-year-old man was treated with a DPP-4 inhibitor for type 2 diabetes. Hypoglycemia occurred frequently, and an examination revealed a tumor with a maximum diameter of 140 mm in both lobes of the liver. Western immunoblotting detected a high-molecular-weight form of insulin-like growth factor-II, and non-islet cell tumor hypoglycemia was diagnosed. Although prednisolone 40 mg was started, hypoglycemia continued to occur frequently. Surgical tumor removal was not indicated, so lenvatinib was initiated. Hypoglycemia improved quickly, and the tumor shrank until it had partially disappeared. His condition continued to improve, and he was discharged.

責任著者(Corresponding author)

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