Successful Treatment of Nephrotic Syndrome Due to Collapsing Focal Segmental Glomerulosclerosis Accompanied by Acute Interstitial Nephritis

Hisato Shima; Toshio Doi; Takuya Okamoto; Yusuke Higashiguchi; Megumi Harada; Tomoko Inoue; Manabu Tashiro; Seiichiro Wariishi; Norimichi Takamatsu; Kazuhiko Kawahara; Kazuyoshi Okada; Jun Minakuchi

doi:10.2169/internalmedicine.8258-21

CASE REPORTS

Successful Treatment of Nephrotic Syndrome Due to Collapsing Focal Segmental Glomerulosclerosis Accompanied by Acute Interstitial Nephritis

Hisato Shima, Toshio Doi, Takuya Okamoto, Yusuke Higashiguchi, Megumi Harada, Tomoko Inoue, Manabu Tashiro, Seiichiro Wariishi, Norimichi Takamatsu, Kazuhiko Kawahara, Kazuyoshi Okada, Jun Minakuchi

著者情報

キーワード: nephrotic syndrome, collapsing focal segmental glomerulosclerosis, steroid, cyclosporin, low-density lipoprotein apheresis

ジャーナルオープンアクセス

2022 年 61 巻 12 号 p. 1863-1867

DOI https://doi.org/10.2169/internalmedicine.8258-21

Browse “Advance online publication” version

詳細

抄録

A 39-year-old woman was hospitalized for nephrotic syndrome. Laboratory test results showed increased serum creatinine levels and urinary excretions of beta-2-microglobulin, and N-acetyl-beta-D-glucosaminidase. A renal biopsy revealed collapsing focal segmental glomerulosclerosis (FSGS) and acute interstitial nephritis. Despite treatment with pulse steroid followed by oral high-dose glucocorticoids and cyclosporines, heavy proteinuria persisted. After low-density lipoprotein apheresis (LDL-A) therapy was initiated, her proteinuria gradually decreased, leading to complete remission. A repeat renal biopsy after treatment revealed no collapsing glomeruli. Immediate LDL-A should be performed to treat cases of collapsing FSGS poorly responding to other treatments.

責任著者(Corresponding author)

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