Ketoacidosis, Hypertriglyceridemia and Acute Pancreatitis Induced by Soft Drink Polydipsia in a Patient with Occult Central Diabetes Insipidus

Yasutaka Tsujimoto; Tomoaki Nakamura; Jun Onishi; Naoto Ishimaru; Naoko Iwata; Haruki Fujisawa; Atsushi Suzuki; Yoshihisa Sugimura; Kazuo Chihara

doi:10.2169/internalmedicine.7663-21

CASE REPORTS

Ketoacidosis, Hypertriglyceridemia and Acute Pancreatitis Induced by Soft Drink Polydipsia in a Patient with Occult Central Diabetes Insipidus

Yasutaka Tsujimoto, Tomoaki Nakamura, Jun Onishi, Naoto Ishimaru, Naoko Iwata, Haruki Fujisawa, Atsushi Suzuki, Yoshihisa Sugimura, Kazuo Chihara

著者情報

Yasutaka Tsujimoto
Department of Diabetes and Endocrinology, Akashi Medical Center Hospital, Japan
Tomoaki Nakamura
Department of Diabetes and Endocrinology, Akashi Medical Center Hospital, Japan
Jun Onishi
Department of General Internal Medicine, Akashi Medical Center Hospital, Japan
Naoto Ishimaru
Department of General Internal Medicine, Akashi Medical Center Hospital, Japan
Naoko Iwata
Department of Endocrinology and Diabetes, Daido Hospital, Japan
Department of Endocrinology, Diabetes and Metabolism, Fujita Health University, Japan
Haruki Fujisawa
Department of Endocrinology, Diabetes and Metabolism, Fujita Health University, Japan
Atsushi Suzuki
Department of Endocrinology, Diabetes and Metabolism, Fujita Health University, Japan
Yoshihisa Sugimura
Department of Endocrinology, Diabetes and Metabolism, Fujita Health University, Japan
Kazuo Chihara
Department of Diabetes and Endocrinology, Akashi Medical Center Hospital, Japan

キーワード: ketoacidosis, soft drink ketosis, acute pancreatitis, central diabetes insipidus, lymphocytic infundibulo-neurohypophysitis, anti-rabphilin-3A antibody

ジャーナルオープンアクセス

2022 年 61 巻 3 号 p. 365-371

DOI https://doi.org/10.2169/internalmedicine.7663-21

Browse “Advance online publication” version

詳細

抄録

A 21-year-old Japanese man without known diabetes mellitus had abdominal pain. The diagnosis was ketoacidosis and hypertriglyceridemia-induced acute pancreatitis. He had polydipsia and polyuria and had habitually drunk several soft drinks every day for two years. After hospitalization, despite adequate liquid intake, dehydration remained with hypotonic polyuria. Further examinations revealed the coexistence of central diabetes insipidus (CDI), possibly caused by lymphocytic infundibulo-neurohypophysitis, based on anti-rabphilin-3A antibody positivity. Although CDI had been undiagnosed for two years, over-consumption of sugar-rich soft drinks to ease thirst caused ketoacidosis, hypertriglyceridemia, and acute pancreatitis. There are no previous reports of this three-part combination of symptoms caused by CDI.

責任著者(Corresponding author)

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