Delayed-onset Organizing Pneumonia Emerging after Recovery from Coronavirus Disease 2019: A Report of Three Cases Diagnosed Using Transbronchial Cryobiopsy and a Review of the Literature

Sho Nakakubo; Keisuke Kamada; Yu Yamashita; Junichi Nakamura; Munehiro Matsumoto; Hiroshi Horii; Kazuki Sato; Daisuke Morinaga; Masaru Suzuki; Nanase Okazaki; Emi Takakuwa; Yoshihiro Matsuno; Satoshi Konno

doi:10.2169/internalmedicine.9016-21

CASE REPORTS

Delayed-onset Organizing Pneumonia Emerging after Recovery from Coronavirus Disease 2019: A Report of Three Cases Diagnosed Using Transbronchial Cryobiopsy and a Review of the Literature

Sho Nakakubo, Keisuke Kamada, Yu Yamashita, Junichi Nakamura, Munehiro Matsumoto, Hiroshi Horii, Kazuki Sato, Daisuke Morinaga, Masaru Suzuki, Nanase Okazaki, Emi Takakuwa, Yoshihiro Matsuno, Satoshi Konno

著者情報

Sho Nakakubo
Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
Keisuke Kamada
Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
Yu Yamashita
Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
Junichi Nakamura
Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
Munehiro Matsumoto
Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
Hiroshi Horii
Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
Kazuki Sato
Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
Daisuke Morinaga
Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
Masaru Suzuki
Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
Nanase Okazaki
Department of Surgical Pathology, Hokkaido University Hospital, Japan
Emi Takakuwa
Department of Surgical Pathology, Hokkaido University Hospital, Japan
Yoshihiro Matsuno
Department of Surgical Pathology, Hokkaido University Hospital, Japan
Satoshi Konno
Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan

キーワード: COVID-19, organizing pneumonia, transbronchial cryobiopsy, steroid therapy, case report

ジャーナルオープンアクセス

2022 年 61 巻 9 号 p. 1403-1410

DOI https://doi.org/10.2169/internalmedicine.9016-21

Browse “Advance online publication” version

詳細

抄録

We present three cases with an atypical clinical course of organizing pneumonia (OP) secondary to coronavirus disease 2019 (COVID-19). Three patients were discharged with satisfactory improvement after standard steroid therapy for COVID-19. Shortly after the completion of treatment, the patients experienced a flare-up of symptoms. Imaging results showed new lesions in the lungs. Transbronchial lung cryobiopsy showed histological findings consistent with OP in all cases. Steroids were administered, and a good therapeutic response was observed.

This report is the first to describe pathologically confirmed OP that developed after recovery from COVID-19. Careful follow-up is advisable for patients who have recovered from COVID-19.

責任著者(Corresponding author)

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