Acute Interstitial Nephritis with Glomerular Capillary IgA Deposition Following SARS-CoV-2 mRNA Vaccination

Erika Hishida; Yuko Ono; Kazuho Oe; Toshimi Imai; Hiromichi Yoshizawa; Takeo Nakaya; Hirotoshi Kawata; Tetsu Akimoto; Osamu Saito; Daisuke Nagata

doi:10.2169/internalmedicine.1631-23

CASE REPORTS

Acute Interstitial Nephritis with Glomerular Capillary IgA Deposition Following SARS-CoV-2 mRNA Vaccination

Erika Hishida, Yuko Ono, Kazuho Oe, Toshimi Imai, Hiromichi Yoshizawa, Takeo Nakaya, Hirotoshi Kawata, Tetsu Akimoto, Osamu Saito, Daisuke Nagata

著者情報

Erika Hishida
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Yuko Ono
Department of Diagnostic Pathology, Dokkyo Medical University, Japan
Kazuho Oe
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Toshimi Imai
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Hiromichi Yoshizawa
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Takeo Nakaya
Department of Pathology, Jichi Medical University, Japan
Hirotoshi Kawata
Department of Pathology, Jichi Medical University, Japan
Tetsu Akimoto
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Osamu Saito
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Daisuke Nagata
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan

キーワード: SARS-CoV-2, COVID-19, vaccination, acute kidney injury, acute interstitial nephritis, capillary IgA deposition

ジャーナルオープンアクセス

2023 年 62 巻 16 号 p. 2381-2387

DOI https://doi.org/10.2169/internalmedicine.1631-23

詳細

抄録

We herein report a case of acute kidney injury (AKI) presenting as acute interstitial nephritis (AIN) after the first dose of the BNT162b2 mRNA vaccine against coronavirus disease 2019 (COVID-19). A 69-year-old man with a history of diabetes and hypertension presented with AKI 4 days after receiving the vaccine. Despite the administration of methylprednisolone pulse treatment, his renal function worsened, which prompted us to initiate temporal hemodialysis. His renal function subsequently improved, and a renal biopsy confirmed AIN and glomerular capillary IgA deposition without apparent crescents. The clinical history and histological findings suggest a relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and AIN as a rare side effect.

責任著者(Corresponding author)

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