Diffuse Large B-cell Lymphoma Involving an Abundant Infiltration of T Follicular Helper Cells

Keitaro Ishii; Kazuharu Kamachi; Sho Okamoto; Hiroo Katsuya; Mai Fujita; Toshiaki Nagaie; Atsujiro Nishioka; Mariko Yoshimura; Hiroshi Ureshino; Yasushi Kubota; Toshihiko Ando; Tatsuro Watanabe; Mai Takeuchi; Keita Kai; Koichi Ohshima; Shinya Kimura

doi:10.2169/internalmedicine.0521-22

CASE REPORTS

Diffuse Large B-cell Lymphoma Involving an Abundant Infiltration of T Follicular Helper Cells

Keitaro Ishii, Kazuharu Kamachi, Sho Okamoto, Hiroo Katsuya, Mai Fujita, Toshiaki Nagaie, Atsujiro Nishioka, Mariko Yoshimura, Hiroshi Ureshino, Yasushi Kubota, Toshihiko Ando, Tatsuro Watanabe, Mai Takeuchi, Keita Kai, Koichi Ohshima, Shinya Kimura

著者情報

Keitaro Ishii
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Kazuharu Kamachi
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Department of Drug Discovery and Biomedical Sciences, Faculty of Medicine, Saga University, Japan
Sho Okamoto
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Hiroo Katsuya
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Mai Fujita
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Toshiaki Nagaie
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Atsujiro Nishioka
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Mariko Yoshimura
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Hiroshi Ureshino
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Department of Drug Discovery and Biomedical Sciences, Faculty of Medicine, Saga University, Japan
Yasushi Kubota
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Department of Transfusion Medicine and Cell Therapy, Saitama Medical Center, Saitama Medical University, Japan
Toshihiko Ando
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Tatsuro Watanabe
Department of Drug Discovery and Biomedical Sciences, Faculty of Medicine, Saga University, Japan
Mai Takeuchi
Department of Pathology, Kurume University School of Medicine, Japan
Keita Kai
Department of Pathology, Saga University Hospital, Japan
Koichi Ohshima
Department of Pathology, Kurume University School of Medicine, Japan
Shinya Kimura
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Department of Drug Discovery and Biomedical Sciences, Faculty of Medicine, Saga University, Japan

キーワード: DLBCL, THRLBCL, T follicular helper cells

ジャーナルオープンアクセス

2023 年 62 巻 9 号 p. 1335-1340

DOI https://doi.org/10.2169/internalmedicine.0521-22

Browse “Advance online publication” version

詳細

抄録

A 76-year-old man presented with skin plaque and splenic nodules, and diffuse large B-cell lymphoma (DLBCL) with infiltration of T-cells was suspected based on the skin lesions. The disease showed indolent clinical behavior for three months, when systemic lymphadenopathy rapidly evolved. An inguinal lymph node biopsy revealed DLBCL with abundant infiltration of T follicular helper (TFH) cells. A polymerase chain reaction-based analysis of immunoglobulin variable heavy chain showed that the skin, splenic nodules, and inguinal lymph node shared the same clone. This case indicates that the dysregulated infiltration of TFH cells in the tumor microenvironment accelerates the lymphomagenesis and progression of DLBCL.

責任著者(Corresponding author)

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