Becker Muscular Dystrophy Accompanied by Anti-HMGCR Antibody-positive Immune-mediated Necrotizing Myopathy

Asami Munekane; Yutaka Ohsawa; Mariko Okubo; Taiji Nagai; Hirotake Nishimura; Ichizo Nishino; Yoshihide Sunada

doi:10.2169/internalmedicine.0202-22

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

Becker Muscular Dystrophy Accompanied by Anti-HMGCR Antibody-positive Immune-mediated Necrotizing Myopathy

Asami Munekane, Yutaka Ohsawa, Mariko Okubo, Taiji Nagai, Hirotake Nishimura, Ichizo Nishino, Yoshihide Sunada

著者情報

キーワード: Becker muscular dystrophy, anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody, immune-mediated necrotizing myopathy

ジャーナルオープンアクセス早期公開

論文ID: 0202-22

DOI https://doi.org/10.2169/internalmedicine.0202-22

この記事には本公開記事があります。

The final version of this article is now available: Vol. 62 (2023), No. 9 pp. 1345-1349

詳細

抄録

Becker muscular dystrophy (BMD) is an X-linked neuromuscular disease characterized by progressive muscle weakness that currently has no cure. Immune-mediated necrotizing myopathy (IMNM) is a type of autoimmune inflammatory myopathy characterized by proximal muscle weakness that is treated with immunosuppressive therapy. We herein report a patient diagnosed with BMD complicated with IMNM by a pathological analysis. Notably, the patient had an elevated serum anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody level. Oral glucocorticoid and methotrexate treatment partially improved the muscle weakness with decreased levels of serum creatine kinase. An accurate diagnosis is important for therapeutic decisions in these complicated cases.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）