A Case of Helicobacter pylori-negative Gastric Adenocarcinoma Mimicking Verrucous Gastritis in the Antrum: A Case Report and Literature Review

Yoshiyuki Murawaki; Kazuo Yashima; Satoshi Horie; Masahiko Miura; Jun Kato; Takayuki Hirai; Kazuki Takeda; Michimori Kono; Manabu Yoshida; Hajime Isomoto

doi:10.2169/internalmedicine.0246-22

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A Case of Helicobacter pylori-negative Gastric Adenocarcinoma Mimicking Verrucous Gastritis in the Antrum: A Case Report and Literature Review

Yoshiyuki Murawaki, Kazuo Yashima, Satoshi Horie, Masahiko Miura, Jun Kato, Takayuki Hirai, Kazuki Takeda, Michimori Kono, Manabu Yoshida, Hajime Isomoto

著者情報

キーワード: Helicobacter pylori-negative, gastrointestinal phenotype, differentiated gastric adenocarcinoma

ジャーナルオープンアクセス早期公開

論文ID: 0246-22

DOI https://doi.org/10.2169/internalmedicine.0246-22

この記事には本公開記事があります。

The final version of this article is now available: Vol. 62 (2023), No. 14 pp. 2063-2069

詳細

抄録

A 46-year-old man was referred to our hospital for the examination of a flat elevated lesion with an erosion-like depression, located on the greater curvature of the antrum. Endoscopic submucosal dissection was performed. Histological findings of the resected specimen demonstrated a well-differentiated tubular adenocarcinoma with a diameter of 12 mm. No atrophy was observed in the tumor-adjacent mucosa. Serum Helicobacter pylori antibody estimation and ¹³C-urea breath tests yielded negative results. Immunohistochemical staining was positive for both gastric mucin and intestinal mucin. The final diagnosis was well-differentiated tubular adenocarcinoma with a gastrointestinal phenotype that originated in mucosa uninfected by H. pylori.

責任著者(Corresponding author)

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