Efficacy of On-line Hemodiafiltration for Rhabdomyolysis Presenting with Acute Kidney Injury due to Unexpected Drug Abuse

Naokazu Sato; Koji Inagaki; Masahiro Takanashi; Reiko Muto; Noritoshi Kato; Shoichi Maruyama; Toshiyuki Akahori

doi:10.2169/internalmedicine.1107-22

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Efficacy of On-line Hemodiafiltration for Rhabdomyolysis Presenting with Acute Kidney Injury due to Unexpected Drug Abuse

Naokazu Sato, Koji Inagaki, Masahiro Takanashi, Reiko Muto, Noritoshi Kato, Shoichi Maruyama, Toshiyuki Akahori

著者情報

キーワード: drug abuse, methamphetamine, rhabdomyolysis, acute kidney injury, myoglobin, on-line hemodiafiltration

ジャーナルオープンアクセス早期公開

論文ID: 1107-22

DOI https://doi.org/10.2169/internalmedicine.1107-22

この記事には本公開記事があります。

The final version of this article is now available: Vol. 62 (2023), No. 19 pp. 2865-2870

詳細

抄録

Myoglobin is a well-known cause of acute kidney injury (AKI) due to rhabdomyolysis. However, whether or not removing serum myoglobin by on-line hemodiafiltration (OHDF) improves the kidney function remains unclear. We herein report a patient with a history of methamphetamine abuse who developed AKI due to rhabdomyolysis. A urinalysis and blood collection results obtained before and after OHDF demonstrated that OHDF improved the kidney function by removing a large amount of serum myoglobin rather than via urinary excretion. In conclusion, OHDF may prevent AKI progression effectively when the urine volume is insufficient.

責任著者(Corresponding author)

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