IgG4-related Disease Emerging after COVID-19 mRNA Vaccination: A Case Report

Satsuki Aochi; Masaaki Uehara; Motohisa Yamamoto

doi:10.2169/internalmedicine.1125-22

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IgG4-related Disease Emerging after COVID-19 mRNA Vaccination: A Case Report

Satsuki Aochi, Masaaki Uehara, Motohisa Yamamoto

著者情報

キーワード: COVID-19, IgG4-related disease, mRNA vaccination

ジャーナルオープンアクセス早期公開

論文ID: 1125-22

DOI https://doi.org/10.2169/internalmedicine.1125-22

この記事には本公開記事があります。

The final version of this article is now available: Vol. 62 (2023), No. 10 pp. 1547-1551

詳細

抄録

A 78-year-old Japanese woman with no history of rheumatic disease received 2 doses of the BNT162b2 COVID-19 mRNA vaccine. Two weeks later, she noticed bilateral swelling in the submandibular region. Blood tests showed hyper-immunoglobulin (Ig)G4emia, and ¹⁸F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) revealed the strong accumulation of FDG in the enlarged pancreas. She was diagnosed with IgG4-related disease (IgG4-RD) according to the American College of Rheumatology (ACR)/the European League Against Rheumatism (EULAR) classification criteria. Treatment was started with prednisolone at 30 mg/day, and the organ enlargement improved. We herein report a case of IgG4-RD that may have been associated with an mRNA vaccine.

責任著者(Corresponding author)