Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Parkinsonism relating to intoxication with glyphosate: A case report
Makoto EriguchiKotaro IidaShuhei IkedaManabu OsoegawaKenya NishiokaNobutaka HattoriHiroshi NagayamaHideo Hara
ジャーナル オープンアクセス 早期公開

論文ID: 2028-18


We herein report the case of a 38-year-old man who developed parkinsonism 4 years after ingesting glyphosate. The patient presented with right-sided bradykinesia and cogwheel rigidity without autonomic symptoms. Magnetic resonance imaging of the brain and [123I]-metaiodobenzylguanidine myocardial scintigraphy were normal. A drastic response to levodopa and the presence of levodopa-induced dyskinesia without strong non-motor symptoms were seen in this patient. We considered that young-onset atypical parkinsonism was associated with a history of sublethal glyphosate ingestion. Epidemiologic investigations have shown that exposure to pesticides is a risk factor for Parkinson' s disease (PD). Our findings support the notion that glyphosate exposure might be related to the onset of PD.

© 2019 by The Japanese Society of Internal Medicine
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