Serum Cytokine Changes in a Patient with Chronic Pulmonary Aspergillosis Overlapping with Allergic Bronchopulmonary Aspergillosis: A Case Report

Yusei Tsukamoto; Yuya Ito; Yasushi Obase; Takahiro Takazono; Nana Nakada; Nobuyuki Ashizawa; Tatsuro Hirayama; Kazuaki Takeda; Shotaro Ide; Naoki Iwanaga; Masato Tashiro; Naoki Hosogaya; Susumu Fukahori; Chizu Fukushima; Katsunori Yanagihara; Koichi Izumikawa; Hiroshi Mukae

doi:10.2169/internalmedicine.2234-23

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Serum Cytokine Changes in a Patient with Chronic Pulmonary Aspergillosis Overlapping with Allergic Bronchopulmonary Aspergillosis: A Case Report

Yusei Tsukamoto, Yuya Ito, Yasushi Obase, Takahiro Takazono, Nana Nakada, Nobuyuki Ashizawa, Tatsuro Hirayama, Kazuaki Takeda, Shotaro Ide, Naoki Iwanaga, Masato Tashiro, Naoki Hosogaya, Susumu Fukahori, Chizu Fukushima, Katsunori Yanagihara, Koichi Izumikawa, Hiroshi Mukae

著者情報

Yusei Tsukamoto
Department of Respiratory Medicine, Nagasaki University Hospital, Japan
Yuya Ito
Department of Respiratory Medicine, Nagasaki University Hospital, Japan
Yasushi Obase
Department of Respiratory Medicine, Nagasaki University Hospital, Japan
Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Takahiro Takazono
Department of Respiratory Medicine, Nagasaki University Hospital, Japan
Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Japan
Nana Nakada
Department of Respiratory Medicine, Nagasaki University Hospital, Japan
Nobuyuki Ashizawa
Department of Respiratory Medicine, Nagasaki University Hospital, Japan
Infection Control and Education Center, Nagasaki University Hospital, Japan
Tatsuro Hirayama
Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, Japan
Kazuaki Takeda
Department of Respiratory Medicine, Nagasaki University Hospital, Japan
Shotaro Ide
Department of Respiratory Medicine, Nagasaki University Hospital, Japan
Infectious Diseases Experts Training Center, Nagasaki University Hospital, Japan
Naoki Iwanaga
Department of Respiratory Medicine, Nagasaki University Hospital, Japan
Masato Tashiro
Department of Respiratory Medicine, Nagasaki University Hospital, Japan
Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Japan
Infection Control and Education Center, Nagasaki University Hospital, Japan
Naoki Hosogaya
Clinical Research Center, Nagasaki University Hosipital, Japan
Susumu Fukahori
Department of Respiratory Medicine, Nagasaki University Hospital, Japan
Chizu Fukushima
Clinical Research Center, Nagasaki University Hosipital, Japan
Katsunori Yanagihara
Department of Laboratory Medicine, Nagasaki University Hospital, Japan
Koichi Izumikawa
Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Japan
Infection Control and Education Center, Nagasaki University Hospital, Japan
Hiroshi Mukae
Department of Respiratory Medicine, Nagasaki University Hospital, Japan
Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan

キーワード: Allergic bronchopulmonary aspergillosis (ABPA), chronic pulmonary aspergillosis (CPA), IL-10, IL-33

ジャーナルオープンアクセス早期公開

論文ID: 2234-23

DOI https://doi.org/10.2169/internalmedicine.2234-23

この記事には本公開記事があります。

The final version of this article is now available: Vol. 63 (2024), No. 11 pp. 1659-1664

詳細

抄録

Allergic bronchopulmonary aspergillosis (ABPA) and chronic pulmonary aspergillosis (CPA) are diseases caused by Aspergillus infection, and CPA can develop from ABPA in some cases. We herein report a patient with CPA overlapping with ABPA. Serum cytokine levels were evaluated at 4 time points: the ABPA diagnosis, CPA diagnosis, 6 months after the start of voriconazole (VRCZ), and 12 months after re-administration of VRCZ. Interleukin (IL)-13 levels decreased upon glucocorticoid treatment, whereas IL-25 and IL-33 levels decreased rapidly with the initiation of antifungals. Early antifungal therapy may be important to control disease progression and prevent CPA overlap.

責任著者(Corresponding author)

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