Association of Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease with Coronavirus Disease 2019 Vaccination and Infection: A Case Report of Cortical Encephalitis and Transverse Myelitis Relapse

Yohei Himeno; Takahisa Tateishi; Ken-Ichi Irie; Shuntaro Ueno; Makoto Morimitsu; Shino Mizoguchi; Tamon Koga; Takayuki Taniwaki

doi:10.2169/internalmedicine.2471-23

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引用する場合も本公開記事を引用してください。

Association of Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease with Coronavirus Disease 2019 Vaccination and Infection: A Case Report of Cortical Encephalitis and Transverse Myelitis Relapse

Yohei Himeno, Takahisa Tateishi, Ken-Ichi Irie, Shuntaro Ueno, Makoto Morimitsu, Shino Mizoguchi, Tamon Koga, Takayuki Taniwaki

著者情報

Yohei Himeno
Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan
Takahisa Tateishi
Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan
Ken-Ichi Irie
Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan
Shuntaro Ueno
Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan
Makoto Morimitsu
Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan
Shino Mizoguchi
Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan
Tamon Koga
Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan
Takayuki Taniwaki
Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan

キーワード: Anti MOG antibody, MOG antibody associated disorder, COVID-19 vaccination, Cortical encephalitis, COVID-19 infection, Transverse myelitis

ジャーナルオープンアクセス早期公開

論文ID: 2471-23

DOI https://doi.org/10.2169/internalmedicine.2471-23

この記事には本公開記事があります。

The final version of this article is now available: Vol. 62 (2023), No. 23 pp. 3549-3554

詳細

抄録

We herein report a case of myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) that occurred following coronavirus disease 2019 (COVID-19) vaccination and its subsequent relapse after COVID-19 infection. A 34-year-old woman developed cortical encephalitis in the right temporoparietal lobe one week after receiving the mRNA-1273 vaccine. The cerebrospinal fluid was positive for anti-MOG antibody. Her symptoms gradually improved after three courses of intravenous methylprednisolone therapy. Six months later, she experienced a relapse of transverse myelitis following COVID-19 infection. Despite treatment with plasma exchange, the patient remained paralyzed in both lower limbs. We herein review the relationship between MOGAD and COVID-19 vaccination/infection.

責任著者(Corresponding author)

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