Immune-mediated Necrotizing Myopathy in a Patient with Microscopic Polyangiitis: A Case Report

Daichi Umemoto; Yohei Kanzawa; Tomoko Nakamura; Ichizo Nishino; Shimpei Mizuki; Jun Ohnishi; Takahiro Nakajima; Naoto Ishimaru; Saori Kinami

doi:10.2169/internalmedicine.2583-23

Daichi Umemoto, Yohei Kanzawa, Tomoko Nakamura, Ichizo Nishino, Shimpei Mizuki, Jun Ohnishi, Takahiro Nakajima, Naoto Ishimaru, Saori Kinami

著者情報

Daichi Umemoto
Department of General Internal Medicine, Akashi Medical Center, Japan
Yohei Kanzawa
Department of General Internal Medicine, Akashi Medical Center, Japan
Tomoko Nakamura
Department of Rheumatology, Akashi Medical Center, Japan
Ichizo Nishino
Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan
Shimpei Mizuki
Department of General Internal Medicine, Akashi Medical Center, Japan
Jun Ohnishi
Department of General Internal Medicine, Akashi Medical Center, Japan
Takahiro Nakajima
Department of General Internal Medicine, Akashi Medical Center, Japan
Naoto Ishimaru
Department of General Internal Medicine, Akashi Medical Center, Japan
Saori Kinami
Department of General Internal Medicine, Akashi Medical Center, Japan

キーワード: Immune-Mediated Necrotizing Myopathy, seronegative, Anti-Neutrophil Cytoplasmic Antibody-associated Vasculitis, Microscopic polyangiitis, connective tissue diseases

ジャーナルオープンアクセス早期公開

論文ID: 2583-23

DOI https://doi.org/10.2169/internalmedicine.2583-23

詳細

抄録

We herein report a case of immune-mediated necrotizing myopathy (IMNM) in a patient with microscopic polyangiitis (MPA). A 77-year-old Japanese woman presented with a 2-day history of proximal muscle weakness and myalgia, with elevated serum creatinine kinase (CK) levels. Findings of a muscle biopsy were compatible with IMNM; however, anti-SRP and anti-HMGCR antibodies were negative. She also had peripheral neuropathy with elevated serum MPO-ANCA titers, leading to a diagnosis of MPA. IMNM can be a pathological result of MPA muscle involvement.

責任著者(Corresponding author)

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