Nivolumab-induced Thrombotic Thrombocytopenic Purpura in Patients with Gastric Tube Cancer

Yuya Yoshida; Sakura Toriyabe; Hiroo Imai; Keiju Sasaki; Yuki Kasahara; Kota Ouchi; Ken Saijo; Koichi Onodera; Chikashi Ishioka

doi:10.2169/internalmedicine.2931-23

Yuya Yoshida, Sakura Toriyabe, Hiroo Imai, Keiju Sasaki, Yuki Kasahara, Kota Ouchi, Ken Saijo, Koichi Onodera, Chikashi Ishioka

著者情報

Yuya Yoshida
Department of Medical Oncology, Tohoku University Hospital, Japan
Sakura Toriyabe
Department of Medical Oncology, Tohoku University Hospital, Japan
Hiroo Imai
Department of Medical Oncology, Tohoku University Hospital, Japan
Keiju Sasaki
Department of Medical Oncology, Tohoku University Hospital, Japan
Yuki Kasahara
Department of Medical Oncology, Tohoku University Hospital, Japan
Kota Ouchi
Department of Medical Oncology, Tohoku University Hospital, Japan
Ken Saijo
Department of Medical Oncology, Tohoku University Hospital, Japan
Koichi Onodera
Department of Hematology, Tohoku University Hospital, Japan
Chikashi Ishioka
Department of Medical Oncology, Tohoku University Hospital, Japan

キーワード: thrombotic thrombocytopenic purpura, gastric tube cancer, hematological adverse events, nivolumab, immunotherapy-related adverse events, immune checkpoint inhibitor

ジャーナルオープンアクセス早期公開

論文ID: 2931-23

DOI https://doi.org/10.2169/internalmedicine.2931-23

詳細

抄録

Recently, immune checkpoint inhibitors (ICIs) have been used to treat several cancer types. ICIs have been reported to cause a wide variety of immune-related adverse events, including endocrine, neurologic, gastrointestinal, and cutaneous disorders. Thrombotic thrombocytopenic purpura (TTP) is an autoimmune hematologic disorder characterized by the presence of autoantibodies against a disintegrin and metalloprotease with thrombospondin-1, member 13. Several previous cases of TTP were thought to have been caused by ICI treatment. We herein report a rare case of TTP that developed after long-term treatment with an ICI (nivolumab) for gastric tube cancer.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）