Intravenous Thrombolysis for Pediatric Ischemic Stroke Secondary to Cancer Therapy-related Cardiac Dysfunction: A Case Report

Futoshi Eto; Tomohisa Nezu; Hideaki Sakahara; Yumiko Yamamoto; Shiro Aoki; Maiko Shimomura; Shuhei Karakawa; Hirofumi Maruyama

doi:10.2169/internalmedicine.3755-24

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Intravenous Thrombolysis for Pediatric Ischemic Stroke Secondary to Cancer Therapy-related Cardiac Dysfunction: A Case Report

Futoshi Eto, Tomohisa Nezu, Hideaki Sakahara, Yumiko Yamamoto, Shiro Aoki, Maiko Shimomura, Shuhei Karakawa, Hirofumi Maruyama

著者情報

Futoshi Eto
Department of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
Tomohisa Nezu
Department of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
Hideaki Sakahara
Department of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
Yumiko Yamamoto
Department of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
Shiro Aoki
Department of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
Maiko Shimomura
Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
Shuhei Karakawa
Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
Hirofumi Maruyama
Department of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan

キーワード: anthracycline, cancer therapy-related cardiac dysfunction, intravenous thrombolysis, left ventricular thrombus, pediatric stroke, transthoracic echocardiography

ジャーナルオープンアクセス早期公開

論文ID: 3755-24

DOI https://doi.org/10.2169/internalmedicine.3755-24

この記事には本公開記事があります。

The final version of this article is now available: Vol. 64 (2025), No. 2 pp. 287-291

詳細

抄録

An 11-year-old boy developed cardioembolic stroke (CES) and cancer therapy-related cardiac dysfunction (CTRCD). He originally developed Ewing sarcoma and was treated with high-dose chemotherapy including doxorubicin. On admission, he had severe aphasia, and magnetic resonance imaging showed occlusion of the left middle cerebral artery M3 segment. Transthoracic echocardiography revealed severe left ventricular dysfunction and a mobile thrombus at the left ventricular apex. Intravenous thrombolysis was administered, and effective recanalization was achieved. The patient did not exhibit any neurological deficits during discharge. Reperfusion therapy for pediatric patients has not yet been established; however, it may be effective for CES secondary to CTRCD.

責任著者(Corresponding author)

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