Diffuse Large B-cell Lymphoma Complicated with Anti-3-hydroxy-3-methylglutaryl-Coenzyme A Reductase Immune-mediated Necrotizing Myopathy: A Case Report

Yoshihiro Tokunaga; Masaru Akiyama; Kohei Nakano; Kiminori Konaka; Akihiko Taguchi; Toshihiko Maeda; Ryota Sato; Takashi Kanda; Yukinori Nakamura; Toshiaki Yujiri; Yasuharu Ohta

doi:10.2169/internalmedicine.3880-24

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引用する場合も本公開記事を引用してください。

Diffuse Large B-cell Lymphoma Complicated with Anti-3-hydroxy-3-methylglutaryl-Coenzyme A Reductase Immune-mediated Necrotizing Myopathy: A Case Report

Yoshihiro Tokunaga, Masaru Akiyama, Kohei Nakano, Kiminori Konaka, Akihiko Taguchi, Toshihiko Maeda, Ryota Sato, Takashi Kanda, Yukinori Nakamura, Toshiaki Yujiri, Yasuharu Ohta

著者情報

Yoshihiro Tokunaga
Department of Endocrinology, Metabolism, Hematological Science and Therapeutics, Yamaguchi University Graduate School of Medicine, Japan
Masaru Akiyama
Department of Endocrinology, Metabolism, Hematological Science and Therapeutics, Yamaguchi University Graduate School of Medicine, Japan
Kohei Nakano
Department of Endocrinology, Metabolism, Hematological Science and Therapeutics, Yamaguchi University Graduate School of Medicine, Japan
Kiminori Konaka
Department of Endocrinology, Metabolism, Hematological Science and Therapeutics, Yamaguchi University Graduate School of Medicine, Japan
Akihiko Taguchi
Department of Endocrinology, Metabolism, Hematological Science and Therapeutics, Yamaguchi University Graduate School of Medicine, Japan
Toshihiko Maeda
Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Japan
Ryota Sato
Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Japan
Takashi Kanda
Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Japan
Neuromuscular Center, Yoshimizu Hospital, Japan
Yukinori Nakamura
Department of Endocrinology, Metabolism, Hematological Science and Therapeutics, Yamaguchi University Graduate School of Medicine, Japan
Toshiaki Yujiri
Department of Endocrinology, Metabolism, Hematological Science and Therapeutics, Yamaguchi University Graduate School of Medicine, Japan
Department of Laboratory Science, Yamaguchi University Graduate School of Medicine, Japan
Yasuharu Ohta
Department of Endocrinology, Metabolism, Hematological Science and Therapeutics, Yamaguchi University Graduate School of Medicine, Japan

キーワード: statin, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), immune-mediated necrotizing myopathy (IMNM), diffuse large B-cell lymphoma

ジャーナルオープンアクセス早期公開

論文ID: 3880-24

DOI https://doi.org/10.2169/internalmedicine.3880-24

この記事には本公開記事があります。

The final version of this article is now available: Vol. 64 (2025), No. 4 pp. 589-595

詳細

抄録

A 75-year-old woman presented with significant muscle weakness after statin use. A muscle biopsy revealed necrotizing myopathy, and the patient tested positive for serum anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies, leading to a diagnosis of anti-HMGCR immune-mediated necrotizing myopathy (IMNM). Computed tomography revealed intraperitoneal lymphadenopathy, which was diagnosed as a diffuse large B-cell lymphoma. Immunostaining confirmed HMGCR expression in the lymphoma cells. The patient received chemotherapy and achieved complete remission of the lymphoma, along with nearly complete recovery from IMNM. Although the etiologies of IMNM and lymphoma remain unclear, HMGCR expression in lymphoma cells is likely to be associated with the development of IMNM.

責任著者(Corresponding author)

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