A Case of Disseminated Mycobacterium avium Infection Complicated with Chylous Ascites in a Patient with Neutralizing Autoantibodies to Interferon-γ

Yusuke Yamaba; Osamu Takakuwa; Ziren Wang; Manami Saito; Daisuke Kawae; Misuzu Yoshihara; Eiji Kunii; Yutaka Ito; Kenji Akita

doi:10.2169/internalmedicine.3987-19

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引用する場合も本公開記事を引用してください。

A Case of Disseminated Mycobacterium avium Infection Complicated with Chylous Ascites in a Patient with Neutralizing Autoantibodies to Interferon-γ

Yusuke Yamaba, Osamu Takakuwa, Ziren Wang, Manami Saito, Daisuke Kawae, Misuzu Yoshihara, Eiji Kunii, Yutaka Ito, Kenji Akita

著者情報

Yusuke Yamaba
Department of Respiratory Medicine, Nagoya City West Medical Center, Japan
Osamu Takakuwa
Department of Respiratory Medicine, Nagoya City West Medical Center, Japan
Department of Education and Research Center for Advanced Medicine, Japan
Ziren Wang
Department of Respiratory Medicine, Nagoya City West Medical Center, Japan
Manami Saito
Department of Respiratory Medicine, Nagoya City West Medical Center, Japan
Daisuke Kawae
Department of Respiratory Medicine, Nagoya City West Medical Center, Japan
Misuzu Yoshihara
Department of Respiratory Medicine, Nagoya City West Medical Center, Japan
Eiji Kunii
Department of Respiratory Medicine, Nagoya City West Medical Center, Japan
Yutaka Ito
Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Japan
Kenji Akita
Department of Respiratory Medicine, Nagoya City West Medical Center, Japan

キーワード: IFN-γAb, chylous ascites, disseminated nontuberculous mycobacteriosis

ジャーナルオープンアクセス早期公開

論文ID: 3987-19

DOI https://doi.org/10.2169/internalmedicine.3987-19

この記事には本公開記事があります。

The final version of this article is now available: Vol. 59 (2020), No. 24 pp. 3195-3200

詳細

抄録

A 68-year-old man visited our hospital due to anorexia, weight loss and a fever. We diagnosed the patient with disseminated Mycobacterium avium complex (MAC) and confirmed the presence of interferon (IFN)-γ neutralizing autoantibodies (IFN-γAb). His lesions improved following antibiotic therapy, but chylous ascites (CA) developed seven months after treatment. CA was able to be controlled by subcutaneous octreotide and diet therapy. IFN-γAb is recognized as having a critical role in the pathogenesis of disseminated MAC disease, but its clinical features are not fully understood. CA may be a complication that develops during the treatment of disseminated MAC infection.

責任著者(Corresponding author)

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