Disseminated Nocardiosis in Idiopathic CD4 Lymphocytopenia: A Rare Case and Literature Review

Nayuta Seto; Takayuki Suzuki; Takahiko Fukuchi; Momori Honjo; Shinya Watanabe; Longzhu Cui; Hitoshi Sugawara

doi:10.2169/internalmedicine.4984-24

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

Disseminated Nocardiosis in Idiopathic CD4 Lymphocytopenia: A Rare Case and Literature Review

Nayuta Seto, Takayuki Suzuki, Takahiko Fukuchi, Momori Honjo, Shinya Watanabe, Longzhu Cui, Hitoshi Sugawara

著者情報

キーワード: Idiopathic CD4 lymphocytopenia, immunologic deficiency syndromes, opportunistic infections, Nocardia, bacteremia, brain abscess

ジャーナルオープンアクセス早期公開

論文ID: 4984-24

DOI https://doi.org/10.2169/internalmedicine.4984-24

この記事には本公開記事があります。

The final version of this article is now available: Vol. 64 (2025), No. 18 pp. 2797-2803

詳細

抄録

Nocardiosis typically affects immunocompromised patients; however, the clinical characteristics of idiopathic CD4 lymphocytopenia (ICL) remain poorly understood. A 64-year-old patient was diagnosed with ICL following disseminated nocardiosis, including bacteremia, pneumonia, knee arthritis, and brain abscess. The patient underwent trimethoprim-sulfamethoxazole therapy with frequent dose adjustments based on the renal function, ranging from 2 to 12 single-strength tablets daily over 5 months of hospitalization. While he had a 1-year uneventful course of lifelong prophylaxis, he experienced prolonged recovery in physical activity. A literature review highlighted the life-threatening nature of nocardiosis in ICL, underscoring the importance of a timely diagnosis and tailored management strategies.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）