Latent Tubulointerstitial Nephritis with IgM-positive Plasma Cells Uncovered in a Case of IgA Nephropathy and Primary Biliary Cholangitis: Clinical and Histological Insights

Ryosuke Saiki; Kan Katayama; Enyo Akiyama; Keiko Oda; Yasuo Suzuki; Tomohiro Murata; Naoki Takahashi; Kaoru Dohi

doi:10.2169/internalmedicine.5217-24

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Latent Tubulointerstitial Nephritis with IgM-positive Plasma Cells Uncovered in a Case of IgA Nephropathy and Primary Biliary Cholangitis: Clinical and Histological Insights

Ryosuke Saiki, Kan Katayama, Enyo Akiyama, Keiko Oda, Yasuo Suzuki, Tomohiro Murata, Naoki Takahashi, Kaoru Dohi

著者情報

キーワード: IgA nephropathy, Tubulointerstitial nephritis with IgM-positive plasma cells, anti-mitochondrial antibody

ジャーナルオープンアクセス早期公開

論文ID: 5217-24

DOI https://doi.org/10.2169/internalmedicine.5217-24

この記事には本公開記事があります。

The final version of this article is now available: Vol. 64 (2025), No. 22 pp. 3266-3271

詳細

抄録

Patients with anti-mitochondrial antibody positivity rarely develop tubulointerstitial nephritis with IgM-positive plasma cells (IgMPC-TIN). A previous report observed elevated serum IgM and urinary β2 microglobulin levels in all cases of IgMPC-TIN. This case involved IgA nephropathy with latent coexisting IgMPC-TIN; however, no such changes were observed. These results suggest that some patients with primary biliary cholangitis may have latent IgMPC-TIN without specific urine or blood results. Furthermore, the patient simultaneously developed IgA nephropathy and IgMPC-TIN, suggesting that the triggers and exacerbating factors for both conditions share a common underlying cause.

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