Loeffler Endocarditis with Antineutrophil Cytoplasmic Antibody-associated Vasculitis after COVID-19 Vaccination

Hiroaki Kawano; Mizuna Otsuka; Masataka Umeda; Tomohisa Uchida; Takako Minami; Tsuyoshi Yoshimuta; Atsushi Kawakami; Koji Maemura

doi:10.2169/internalmedicine.5475-25

Hiroaki Kawano, Mizuna Otsuka, Masataka Umeda, Tomohisa Uchida, Takako Minami, Tsuyoshi Yoshimuta, Atsushi Kawakami, Koji Maemura

Author information

Hiroaki Kawano
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Mizuna Otsuka
Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Masataka Umeda
Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Tomohisa Uchida
Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Takako Minami
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Tsuyoshi Yoshimuta
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Atsushi Kawakami
Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Koji Maemura
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan

Keywords: ANCA, endocarditis, infection, vaccination

JOURNAL OPEN ACCESS Advance online publication

Article ID: 5475-25

DOI https://doi.org/10.2169/internalmedicine.5475-25

Details

Abstract

A 71-year-old Japanese woman was hospitalized for heart failure with Loeffler endocarditis, bronchial asthma, fever, and mononeuritis multiplex after receiving the fifth dose of the COVID-19 vaccine. Laboratory tests revealed eosinophilia and increased antineutrophil cytoplasmic antibody levels. The patient's condition improved after anticoagulant therapy.

Loeffler endocarditis with antineutrophil cytoplasmic antibody-associated vasculitis may be associated with the COVID-19 vaccination.

Corresponding author

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