Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918

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Sinus Node Dysfunction Co-occurring with Immune Checkpoint Inhibitor-associated Myocarditis: A Case Report
Tatsuya NishikawaKei KunimasaKeiko Ohta-OgoYoshihiko IkedaTaku YasuiWataru ShioyamaToru OkaKeiichiro HonmaKinta HatakeyamaToru KumagaiMasashi Fujita
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ジャーナル オープンアクセス 早期公開

論文ID: 8575-21

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Immune checkpoint inhibitor (ICI)-induced myocarditis is a potentially life-threatening adverse event. We herein report a rare case of sick sinus syndrome (SSS) co-occurring with ICI-associated myocarditis. A 71-year-old woman with lung cancer undergoing pembrolizumab monotherapy was admitted owing to a fever, worsening kidney function, and sinus bradycardia. She was diagnosed with multi-organ immune-related adverse events, including myocarditis. Pulse steroid therapy was initiated immediately under the support of a temporary pacemaker, which resulted in the resolution of SSS in a few days. Biopsy specimens of the endomyocardium showed active myocarditis. Thus, we should be aware that SSS can co-occur with ICI-induced myocarditis.

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© 2022 by The Japanese Society of Internal Medicine
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