A Rare Monocytic Crisis of Chronic Myelogenous Leukemia Presenting with Unusual Extramedullary Manifestations and an Atypical (14;22)(q24;q11.2) Translocation in the Bone Marrow

Morihiro Inoue; Masao Hagihara; Tomoyuki Uchida; Jian Hua; Takeshi Nakajima; Shogo Tajima; Yasunori Ota

doi:10.2169/internalmedicine.8617-16

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A Rare Monocytic Crisis of Chronic Myelogenous Leukemia Presenting with Unusual Extramedullary Manifestations and an Atypical (14;22)(q24;q11.2) Translocation in the Bone Marrow

Morihiro Inoue, Masao Hagihara, Tomoyuki Uchida, Jian Hua, Takeshi Nakajima, Shogo Tajima, Yasunori Ota

著者情報

キーワード: Monocytic crisis, Philadelphia (Ph) chromosome positive chronic myelogenous leukemia, (14;22)(q24;q11.2) translocation, extramedullary manifestations

ジャーナルオープンアクセス早期公開

論文ID: 8617-16

DOI https://doi.org/10.2169/internalmedicine.8617-16

この記事には本公開記事があります。

The final version of this article is now available: Vol. 56 (2017), No. 24 pp. 3341-3346

詳細

抄録

A 48-year-old man was admitted due to marked leukocytosis. Bone marrow examinations resulted in a diagnosis of Philadelphia (Ph) chromosome-positive chronic myeloid leukemia. One month later, massive muscle and bone invasion by leukemic cells was detected. After induction chemotherapy, he complained of a headache and visual loss, which was caused by a leukemic infiltration in the central nervous system. After temporary remission in response to chemotherapy, the disease relapsed in the form of an intracranial tumor. The unusual t(14;22)(q24;q11.2) translocation of the Ph-chromosome and the significant increase in monocytes observed might have contributed to the unique and aggressive clinical course.

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