Inflammatory Thoracic Aortic Aneurysm in a Patient with Advanced Lung Adenocarcinoma Treated with Pembrolizumab

Ryusuke Ninomiya; Yuhei Kinehara; Satoshi Tobita; Hachiro Konaka; Ryu Jokoji; Takashi Shintani; Isao Tachibana

doi:10.2169/internalmedicine.8688-21

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Inflammatory Thoracic Aortic Aneurysm in a Patient with Advanced Lung Adenocarcinoma Treated with Pembrolizumab

Ryusuke Ninomiya, Yuhei Kinehara, Satoshi Tobita, Hachiro Konaka, Ryu Jokoji, Takashi Shintani, Isao Tachibana

著者情報

キーワード: aortitis, inflammatory thoracic aortic aneurysm, immune-related adverse events, pembrolizumab

ジャーナルオープンアクセス早期公開

論文ID: 8688-21

DOI https://doi.org/10.2169/internalmedicine.8688-21

この記事には本公開記事があります。

The final version of this article is now available: Vol. 61 (2022), No. 15 pp. 2339-2341

詳細

抄録

A 57-year-old man with lung adenocarcinoma was treated with chemotherapy and immune checkpoint blockade. After two cycles of carboplatin, pemetrexed, and pembrolizumab, he developed a persistent fever. Chest computed tomography (CT) suggested inflammation of the aortic wall. We treated the patient with corticosteroids. After four cycles of carboplatin, pemetrexed, and pembrolizumab, chest CT showed an aneurysm in the ascending aorta. We diagnosed him with inflammatory thoracic aortic aneurysm induced by pembrolizumab and performed surgical replacement of the ascending aorta. Although this might be a very rare case, we should be aware of aortitis as a potential adverse effect of pembrolizumab.

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