A Patient with Acute Kidney Injury Associated with Massive Proteinuria and Acute Hyperuricemia after Epileptic Seizures

Yoshihiro Tomomitsu; Shinichiro Asakawa; Shigeyuki Arai; Michito Nagura; Kenichi Ishizawa; Osamu Yamazaki; Yoshifuru Tamura; Shunya Uchida; Ryuji Ohashi; Shigeru Shibata; Yoshihide Fujigaki

doi:10.2169/internalmedicine.8808-21

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

A Patient with Acute Kidney Injury Associated with Massive Proteinuria and Acute Hyperuricemia after Epileptic Seizures

Yoshihiro Tomomitsu, Shinichiro Asakawa, Shigeyuki Arai, Michito Nagura, Kenichi Ishizawa, Osamu Yamazaki, Yoshifuru Tamura, Shunya Uchida, Ryuji Ohashi, Shigeru Shibata, Yoshihide Fujigaki

著者情報

キーワード: acute kidney injury, minimal change nephrotic syndrome, seizure, uric acid nephropathy

ジャーナルオープンアクセス早期公開

論文ID: 8808-21

DOI https://doi.org/10.2169/internalmedicine.8808-21

この記事には本公開記事があります。

The final version of this article is now available: Vol. 61 (2022), No. 22 pp. 3401-3408

詳細

抄録

A 25-year-old man presented with acute kidney injury (AKI), massive proteinuria and hyperuricemia after epileptic seizures. His AKI improved along with the disappearance of proteinuria after corticosteroid treatment. A kidney biopsy revealed no significant glomerular abnormalities, but varying degrees of tubular injury, such as proximal tubular simplification, mild distal tubular proliferation, and Tamm-Horsfall protein-like material accumulation with extravasation into the interstitium, were noted. A further analysis revealed the intratubular depositions of uric acid crystals, indicating the involvement of acute uric acid nephropathy associated with seizures. Our patient's condition is rare, and the clinicopathological aspects of the diagnostic challenges are discussed.

責任著者(Corresponding author)

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