Effectiveness of Chemotherapy for Advanced Adenocarcinoma of the Pancreas in Combined Modality Therapy

Hiroyuki KATO; Hideyuki WAKASUGI; Masaki YOKOTA; Masayuki FURUKAWA; Toshio MUKUTA; Yukio YAMADA; Akihiro FUNAKOSHI

doi:10.2169/internalmedicine.33.142

Hiroyuki KATO, Hideyuki WAKASUGI, Masaki YOKOTA, Masayuki FURUKAWA, Toshio MUKUTA, Yukio YAMADA, Akihiro FUNAKOSHI

著者情報

キーワード: 5-fluorouracil, mitomycin C, intraoperative radiotherapy, bypass operation, celiac plexus nerve block

ジャーナルフリー

1994 年 33 巻 3 号 p. 142-146

DOI https://doi.org/10.2169/internalmedicine.33.142

詳細

抄録

Because it is difficult to diagnose at an early stage, pancreatic carcinoma is usually well advanced by the time it is diagnosed. The combined use of intraoperative radiotherapy, gastrointestinal and/or biliary tract bypass operation, celiac plexus nerve block, and chemotherapy is widely applied in treatment, with favorable results reported in some patients with advanced disease. To evaluate the efficacy of chemotherapy in such combinations, we compared the effect of 5-fluorouracil, its analogues, and mitomycin C on the survival of patients with advanced stage pancreatic cancer. We found no significant difference between the patients treated or not treated with these drugs. Clearly, there is a need for new agents having greater efficacy against pancreatic carcinoma.
(Internal Medicine 33:142-146, 1994)

責任著者(Corresponding author)

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