Acquired Idiopathic Pure Red Cell Aplasia in a Hemodialyzed Patient with Inactive Systemic Lupus Erythematosus

Hirokazu OKADA; Hiromichi SUZUKI; Hideo UCHIDA; Yoshihiko KANNO; Yuko KITAMURA; Tadakazu HISAMATSU; Nobuhiro DEGUCHI; Daisuke HAYASHI; Takao SARUTA

doi:10.2169/internalmedicine.33.492

Hirokazu OKADA, Hiromichi SUZUKI, Hideo UCHIDA, Yoshihiko KANNO, Yuko KITAMURA, Tadakazu HISAMATSU, Nobuhiro DEGUCHI, Daisuke HAYASHI, Takao SARUTA

著者情報

キーワード: erythropoietin, corticosteroid, bone marrow stem cell

ジャーナルフリー

1994 年 33 巻 8 号 p. 492-495

DOI https://doi.org/10.2169/internalmedicine.33.492

詳細

抄録

A male patient suffered chronic renal failure due to lupus nephritis and was undergoing hemodialysis. Six years after beginning hemodialysis, anemia developed, which improved by erythropoietin. Unresponsiveness to erythropoietin gradually appeared, and with a suspicion of pure red cell aplasia, he was treated with a high-dose corticosteroid but the unresponsiveness did not improve. Neither his serum nor lymphocytes inhibited erythropoiesis of either normal bone marrow stem cells or his own in vitro. These observations suggest an impaired hematopoietic microenvironment in his bone marrow.
(Internal Medicine 33: 492-495, 1994)

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