Acquired Factor VIII-Specific Antibody Disorder Accompanied by a Life-Threatening Retroperitoneal Hematoma

Eiji KONDO; Makoto UTSUMI; Mamiko HATTORI; Keitaro TSUSHITA; Yousuke NAKAHARA; Masao TANAKA; Junki TAKAMATSU

doi:10.2169/internalmedicine.34.901

Eiji KONDO, Makoto UTSUMI, Mamiko HATTORI, Keitaro TSUSHITA, Yousuke NAKAHARA, Masao TANAKA, Junki TAKAMATSU

著者情報

キーワード: acquired factor VIII deficiency, retroperitoneal hematoma

ジャーナルフリー

1995 年 34 巻 9 号 p. 901-903

DOI https://doi.org/10.2169/internalmedicine.34.901

詳細

抄録

A male patient, aged 58, without any discernible underlying disease developed a massive hemorrhage in the retroperitoneal cavity and in the femoral muscle. The hemorrhagic tendency of the patient was found to be due to the acquired anti-Factor VIII specific autoantibody in the blood. A concentrate of an activated prothrombin complex (FEIBA: Factor eight inhibitor bypassing activity) was administered and produced a remarkable effect in stemning the bleeding tendency of the patient. Immunosuppressive therapy was also effective for the control of the bleeding.
(Internal Medicine 34: 901-903, 1995)

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