Myeloperoxidase-Specific Anti-Neutrophil Cytoplasmic Autoantibodies - Related Scleroderma Renal Crisis Treated with Double-Filtration Plasmapheresis

Akiko OMOTE; Masahito MURAMATSU; Yoshiyuki SUGIMOTO; Shimako HOSONO; Ryuichiro MURAKAMI; Hitoshi TANAKA; Yoshiaki WATANABE; Hiroshi SANO; Katsumoto KATO

doi:10.2169/internalmedicine.36.508

Akiko OMOTE, Masahito MURAMATSU, Yoshiyuki SUGIMOTO, Shimako HOSONO, Ryuichiro MURAKAMI, Hitoshi TANAKA, Yoshiaki WATANABE, Hiroshi SANO, Katsumoto KATO

著者情報

Akiko OMOTE
The Department of Internal Medicine, Kamo Hospital
Masahito MURAMATSU
The Department of Internal Medicine, Kamo Hospital
Yoshiyuki SUGIMOTO
The Department of Internal Medicine, Kamo Hospital
Shimako HOSONO
The Department of Internal Medicine, Kamo Hospital
Ryuichiro MURAKAMI
The Department of Internal Medicine, Kamo Hospital
Hitoshi TANAKA
The Department of Internal Medicine, Kamo Hospital
Yoshiaki WATANABE
The Department of Internal Medicine, Kamo Hospital
Hiroshi SANO
The Department of Internal Medicine, Kamo Hospital
Katsumoto KATO
The Department of Internal Medicine, Kamo Hospital

キーワード: systemic sclerosis (SSc), necrotizing crescentic glomerulonephritis, interstitial pneumonia, mizoribine (MZR)

ジャーナルフリー

1997 年 36 巻 7 号 p. 508-513

DOI https://doi.org/10.2169/internalmedicine.36.508

詳細

抄録

A 46-year-old female patient who was diagnosed with systemic sclerosis (SSc) developed rapidly progressive renal failure without elevation of blood pressure or plasma renin concentration. Renal biopsy revealed necrotizing crescentic glomerulonephritis (pauci-immune type) and the myeloperoxidase-speciflc anti-neutrophil cytoplasmic autoantibodies (MPO-ANCA) liter was found to be elevated to 669 EU/ml. Methylprednisolone (MP) pulse therapy followed by prednisolone (PSL) and mizoribine (MZR) did not suppress the progression of renal failure. Therefore, we started double-filtration plasmapheresis (DFPP) which effectively removed MPO-ANCA and prevented renal failure despite the relatively low dose of immunosuppressive agents.
(Internal Medicine 36: 508-513, 1997)

責任著者(Corresponding author)

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