Mechanism of Increased Serum Cytokeratin 19 Fragment Levels in Patients with Diabetic Nephropathy as a Model of Chronic Renal Failure

Kosuke KASHIWABARA; Koji KISHI; Hiroyuki NAKAMURA; Hisanaga YAGYU; Katsuyuki KOBAYASHI; Osamu WATANABE; Takeshi MATSUOKA

doi:10.2169/internalmedicine.37.917

Kosuke KASHIWABARA, Koji KISHI, Hiroyuki NAKAMURA, Hisanaga YAGYU, Katsuyuki KOBAYASHI, Osamu WATANABE, Takeshi MATSUOKA

著者情報

キーワード: urinary cytokeratin 19 fragment (CYFRA 21-1), urinary albumin, urinary transferrin, urinary immunoglobulin G, metabolic failure

ジャーナルフリー

1998 年 37 巻 11 号 p. 917-921

DOI https://doi.org/10.2169/internalmedicine.37.917

詳細

抄録

We examined serum and urinary cytokeratin 19 fragment (CYFRA 21-1) levels in patients with diabetic nephropathy as a model of chronic renal failure, to investigate the mechanism of increased serum CYFRA 21-1 levels in chronic renal failure. Serum and urinary CYFRA 21-1 levels in non-insulin-dependent diabetes mellitus (NIDDM) patients with abnormal urinary immunoglobulin G (IgG) levels (>1.1 mg/g • Cr, n=126) were higher than those with normal urinary IgG levels. In NIDDM patients with normal urinary IgG levels (n=81); the urinary albumin or transferrin levels were not related to serum or urinary CYFRA 21-1 levels. We speculate that the increased serum CYFRA 21-1 levels contribute to metabolic abnormality in the kidney itself rather than the decreased urinary excretion per se, and that increased urinary CYFRA 21-1 levels are found in advanced cases of diabetic nephropathy with destruction of the size barrier.
(Internal Medicine 37: 917-921, 1998)

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