Bronchiectasis with Myeloperoxidase Antineutrophil Cytoplasmic Antibody and Bactericidal/Permeability-Increasing Protein Antineutrophil Cytoplasmic Antibody

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A 56-year-old woman was hospitalized for recurrent hemoptysis. She had been suffering from bronchiectasis for 4 years. Pseudomonas aeruginosa was persistently detected in her sputum. Serum was positive for Myeloperoxidase antineutrophil Cytoplasmic antibody (MPO-ANCA) and bactericidal/permeability-increasing protein antineutrophil Cytoplasmic antibody (BPI-ANCA). She underwent lung resection. Histopathologically, the resected lung showed bronchiectasis with pulmonary fibrosis but did not show vasculitis. Her serum became negative for the ANCAs after the operation. To date, she has no recurrence of hemoptysis. We discuss this case of bronchiectasis with MPO-ANCA and BPI-ANCA and suggest a possible role for ANCAs in chronic airway infection.
(Internal Medicine 38: 813-816, 1999)