Pulse Intravenous Cyclophosphamide Treatment for Steroid-resistant Interstitial Pneumonitis Associated with Polymyositis

Takafumi YOSHIDA; Hironori KOGA; Fumihiko SAITOH; Masaharu SAKAMOTO; Masaru HARADA; Hiroshi YOSHIDA; Shotaro SAKISAKA; Michio SATA

doi:10.2169/internalmedicine.38.733

Takafumi YOSHIDA, Hironori KOGA, Fumihiko SAITOH, Masaharu SAKAMOTO, Masaru HARADA, Hiroshi YOSHIDA, Shotaro SAKISAKA, Michio SATA

著者情報

キーワード: cytotoxic agent, pulmonary fibrosis, connective tissue disease

ジャーナルフリー

1999 年 38 巻 9 号 p. 733-738

DOI https://doi.org/10.2169/internalmedicine.38.733

詳細

抄録

Interstitial pneumonitis (IP) is a serious complication in polymyositis/dermatomyositis (PM/DM), leading to significant morbidity or mortality. Here, we report the successful treatment by pulse intravenous administration of Cyclophosphamide in the early course of lung involvement in PM, and with subsequent low-dosage oral administration of azathioprine in a patient with steroid-resistant IP associated with PM/DM. Although the precise pharmacological mechanism induced by Cyclophosphamide in this disease remains unclear, such a cytotoxic drug raises the possibility of control of steroid-resistant PM/DM-associated IP when used in the early course of IP.
(Internal Medicine 38: 733-738, 1999)

責任著者(Corresponding author)

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