Ulcerative Colitis in Monozygotic Twin Sisters

Moriya IWAIZUMI; Masami YAMADA; Mutsuo KITAGAWA; Yasunori TAKEHIRA; Kazunori HANAJIMA; Gou MUROHISA; Motoko KAWAMURA; Yasushi IWAOKA; Tomohiko WADA; Satoru MORITA; Kazuhito KAWATA

doi:10.2169/internalmedicine.41.629

Moriya IWAIZUMI, Masami YAMADA, Mutsuo KITAGAWA, Yasunori TAKEHIRA, Kazunori HANAJIMA, Gou MUROHISA, Motoko KAWAMURA, Yasushi IWAOKA, Tomohiko WADA, Satoru MORITA, Kazuhito KAWATA

著者情報

キーワード: inflammatory bowel disease, HLA, twins

ジャーナルフリー

2002 年 41 巻 8 号 p. 629-632

DOI https://doi.org/10.2169/internalmedicine.41.629

詳細

抄録

We present a rare occurrence of woman monozygotic twins with ulcerative colitis (UC). A 21-year-old woman came to our hospital because of diarrhea, abdominal pain and hematochezia. We diagnosed this case as proctitis type UC by endoscopic and histological findings. Six months later, her twin sister developed total colitis type UC. Both twins had HLA-A24, B52, DR2, and DQ1 serological types, and had DRB1*1502 DNA type, previously shown to be associated with UC. This case report suggested an association of genetic factor together with environmental factors in the etiology for UC.
(Internal Medicine 41: 629-632, 2002)

責任著者(Corresponding author)

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