抄録
The present paper deals with the effects of Reserpine on 36 psychoses which were treated in our clinic since December 1954. Twenty schizophrenics, five manic depressives, two epilietics, 3 general paresises, two cerebral arterioscleroses, two feeblemindeds and two other cases were studied. 31 cases of the total cases were preveiously treated with EST or other specific treatments.
0.5 mg of Reserpine were given orally for 30-50 days, or 0.5-1.0mg of Reserpine were given initially, and succeedingly the dose was increased to 3-5 mg per day and the last dose of 10-20 mg was continuously administered for 30-50 days.
1) 7 out of the 20 schizophrenics (35.0%) and all of the 5 manic depressives (100%) were much or completely improved, while 4 schizophrenics were unchanged. In two of the two psychomotor epileptics, some degrees of improvement were evident, while most symptoms in the organic psychosis such as general paresis or cerebral arteriosclerosis were unchanged or poorly improved.
2) Reserpine treatment was most effective on emotional disturbances such as irritability, excess or instability, and more effective on catatonic psychomotor disturbances such as negativism, mutism, excitement or stupor than on delusion or hallucination.
3) The group, treated with more than 400 mg of Reserpine, was more improved than the group, treated with less than 400 mg, while better result was found in the group treated for more than 45 days than the group treated for less than 45 days.
4) During the observation period of one year, 6 cases of 16 schizophrenics (37.5%), 3 cases fo 5 manic depressives (60.0%) and one of the two epileptics have recurrented or relapsed.
