抄録
With the purpose of determine if the causative factors of anemia in the patients with hepatoma might be dependent upon the accelerated destruction of erythrocytes or inhibition of hematopoiesis, the author studied the course of the blood picture as well as the manner of maturation of reticulocytes in anemia of rats induced by inoculation of AH-130 ascites hepatoma cells. Autopsy examination of the rats was made.
The hemoglobin content and erythrocyte count decrease day by day after the transplan-tation of hepatoma cells. Those erythrocytes with a large diameter increased in number, but the hemoglobin quotient remained unchanged until the end; while on the contrary, the reticulocyte count increased with the advance in anemia. As for the maturation of reticulocytes, there was an increase in number of aged and emaciated cells. As for the findings on bone marrow young erythroblasts increased in number day by day, while normal erythroblasts decreased in number, demonstrating clearly a delay in the maturation. The spleens were swollen, accompanied by the enlargement or hypertrophic proliferation of reticuloendothelial cells, although there was almost no hemosiderin pigment in the splenic tissue.
From these results, it is concluded that the inhibition of the maturation of erythrocytes appears to be mainly due to the disturbance in the reticuloendothelial system and plays an important role in anemia of the rats induced by transplanting AH-130 ascited hepatoma cells.
