抄録
A series of 40 pulmonary homografts in dogs was studied to evaluate the effect of 6-mercaptopurine. Out of the 40 dogs, 19 dogs, were subjected to treat with 6-MP in conjunction with pulmonary homografting to achieve suppression of the immunological reaction. A control series of 21 dogs was followed up without modification by 6-MP.
Most of the control series died within two weeks after pulmonary homograft with massive pneumonia or pulmonary necrosis. The lungs were grossly reddish brown, consolidated and enlarged five times as large as the normal lungs. The microscopic appearance consisted of mononuclear infiltrates such as lymphocytes and histocytes, starting at the third days postgrafting and demonstrated its terminal changes with pulmonary edema, thrombosis and complete hemorrhagic necrosis at the 10th postoperative days.
Out of the 19 dogs treated with 6-MP, 11 dogs were well affected by the therapy. They survived more than 2 weeks, the longest survival times recorded as late as 75 days post-grafting. Grossly the lungs were not enlarged in size and rather atrophied. Microscopically slight degree of perivascular inflammation was observed at the 7th day post-grafting and there was moderate fibrosis of a lung tissue after the third week post-grafting.
An influence of 6-MP on blood was also studied. There were moderate degree of anemia, i. e. decrease in the Hb content and the red cell count. The total white count increased in the control dogs, while it did not show any noticeable changes in the dogs with 6-MP therapy with exception of the terminal stage in which the white cell count increased.
