The clinical and histopathological observations on the lungs of sixty two premature infants, which were dissected in recent seven years at our hospital, were indicated.
In fifty five cases, incomplete pulmonary dilatation was observed more or less, and one fifth of them was complicated with pulmonary circulatory disturbances, Although these cases were accompanied with kernicterus, neonatal sclerema, intracranial hemorrhage, pulmonary hyaline membrane disease, massive aspiration of amnion debris and abnormal external pressure upon lungs, the fundamental cause of incomplete pulmonary dilatation was considered as “prematurity of the respiratory system”.
The structural alterations of the lungs in premature infants were also discussed in conjunction with clinical and laboratory data.

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Roentgenological and histological studies on injuries of the spinal cords of rabbits were carried out. They received injuries by falling down to the floor from 1 to 2 meter high and were devided into two groups: -the first group was associated with bony injury and the second group without bony injury-and were compared with each other.
The following results were obtained:
1) Edema and swelling of the spinal cord were observed in both the 1st and the 2nd group. Also incomplete fragmentations of the spinal cord were seen in several cases.
2) In the 2nd group, there were regenerative mechanism in young nerve cells.
3) The changes of the nerve cells in the spinal cord injury were caused by not only direct effect of trauma but also bleeding and edema secondarily.

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1% Ogawa's egg slant was used, and pH of its condense water was adjusted 6.8 with HCI and NaOH. Used strains were following 6: H₃₇Rv, Aoyama-B, two strains isolated from sputa of a pulmonary tuberculosis patients never treated (with chemotherapic substances) and 2 strains from those treated cycloserine and other antituberculous drugs. After 3 weeks culture on 1% Ogawa's egg slant, each strain was diluted 10^-2 times by turbidometry and O, 1ml of each emulsions was inoculated.
The influences of Lots of cycloserine to its minimal inhibitory concentration to Myc. tuberculosis were compaired. The potency of cycloserine to Myc, tuberculosis was not influenced by the Lot, when the conditions of strains and the media were kept constant.

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1) We reported two cases with myelopathy due to cervical spondylosis, one case with myelopathy due to calcified lig, longitudinale posterior of upper cervical region, one case with meningioma spreading from posterior cistern to upper cervical region and one case with myelopathy associated with Klippel-Feil syndrome.
2) Clinical manifestations of these cases were very interesting and were discussed in detail comparing with their pathogenetic findings.
3) Lumbal puncture showed important diagnostic value, though myelography came to final decision. Queckenstedt test in retroflexed neck position was noted as a valuable procedure to detect the initial sign of spinal canal block at the level of cervical portion.

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A series of 40 pulmonary homografts in dogs was studied to evaluate the effect of 6-mercaptopurine. Out of the 40 dogs, 19 dogs, were subjected to treat with 6-MP in conjunction with pulmonary homografting to achieve suppression of the immunological reaction. A control series of 21 dogs was followed up without modification by 6-MP.
Most of the control series died within two weeks after pulmonary homograft with massive pneumonia or pulmonary necrosis. The lungs were grossly reddish brown, consolidated and enlarged five times as large as the normal lungs. The microscopic appearance consisted of mononuclear infiltrates such as lymphocytes and histocytes, starting at the third days postgrafting and demonstrated its terminal changes with pulmonary edema, thrombosis and complete hemorrhagic necrosis at the 10th postoperative days.
Out of the 19 dogs treated with 6-MP, 11 dogs were well affected by the therapy. They survived more than 2 weeks, the longest survival times recorded as late as 75 days post-grafting. Grossly the lungs were not enlarged in size and rather atrophied. Microscopically slight degree of perivascular inflammation was observed at the 7th day post-grafting and there was moderate fibrosis of a lung tissue after the third week post-grafting.
An influence of 6-MP on blood was also studied. There were moderate degree of anemia, i. e. decrease in the Hb content and the red cell count. The total white count increased in the control dogs, while it did not show any noticeable changes in the dogs with 6-MP therapy with exception of the terminal stage in which the white cell count increased.

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1) We have thought the new surgical treatment for the chronic constipation, that is the transplantation of the jejunal-graft of 15cm length to the middle part of the quercolon, that graft is a part of distance of ca. 30cm from the treitz's band.
2) In the radiological studies of one year after the operation, the transit of the contrast medium through the colon was rapidly and sufficiently observed the mucosal pattern of the transplantated small intestine.
3) The response of the operation was gratifying, for after the therapy the patient was improved from constipation and abdominal pains.

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In the bone graft, there is an antigen-antibody reaction between the grafted bone and the recipient as one of the factors determining the results.
The authors grafted several kinds of preserved bones, which have been used clinically, to the ulna of the rabbit in order to know appearance of antibody. Precipitin reaction. using serum dilution overlaid method was carried out upon the sera obtained from the rabbits periodically. At the same time, we observed clinical course of osseal fusion by X-ray and obtained the following results.
1) In the case of fresh autogeneous bone graft, precipitin reaction was negative. By X-ray examination osseal fusion was complete in the 4 th week.
2) Titer of precipitin reaction upon heterogeneous preserved bone graft rose rapidly from the third week and it did not decline even in the 6 th week. This is obvious from the poitn mechanism of antigen-antibody reaction which was developed by heterogeneous protein. The X-ray findings showed tendency of separation and necrosis of the grafted bone.
3) As the preservatives for homogeneous preserved bone Hibiten or Merthiolate solution (both 0.1% solution) was used. In both experiments precipitin reaction developed in the second week and the titer was low. In the 6th week, in the majority of the animals the reaction disappeared but in some cases weak reaction remained. Osseal fusion was complete in the 6 th week. No differences in the results due to preservatives used were able to recognize.
4) The Boplant and Kiel Bone were used as the heterogeneous deproteinized bone graft. In the Boplant case, weak precipitin reaction developed in the second week, and the reaction could be detected until the 6 th week, while the reaction was hardly seen throughout if the Kiel Bone was applied for a bone graft. This is thought to be due to difference of degree of deproteinization. Osseal fusion of this heterogeneous bone graft took fairly longer time than the homogeneous preserved bone graft, even so osseal fusion in the deproteinized bone graft was almost complete in the 10 th week. According to the X-ray findings, the Boplant graft showed stimulating effect to the transplanting base and promoted callus formation, while the Kiel Bone graft displayed bone formation as the form of substitution.
5) In the above stated experimental studies on the bone graft, whether precipitin reaction may develop or not could be one of the factors managing the results of bone transplantation, however, the fact that degree of precipitin reaction exhibited no particular correlation between successful osseal fusion and unsuccessful one, was reconfirmed.

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We have recently performed a combined resection of thyroid cancer and the commona carotid artery together with the transplantation of blood vessels and have obtained a favorable effect. The procedure is hereby reported with a review of the literature. This was a 76 years old male patient, who had had a child-fist sized, firm tumor on the left side of the neck. One week prior to surgery, gradual increasing pressure was applied to the common carotid artery to prevent disturbance due to a rapid disruption of blood flow. On October 8, 1965, an operation was carried out under GOF anesthesia at room temperature. The tumor developed from the left lobe of the thyroid and consisted of a firm part and a cystic part. The cystic part was filled with old blood and was attached firmly to the left common carotid artery. The tumor was therefore resected en bloc together with the left common carotid artery and a teflon substitution blood vessel with an internal diameter of 8mm was transplanted, after 7 minutes and 30 seconds of disruption of blood flow through the common carotid artery. Histologically the tumor was follicular adenocarcinoma of Warren and Meissner's classification. The literature was reviewed concerning 1) Safe limit of time of occlusion of the common carotid artery, 2) the method of interruption of blood flow during the reconstruction of the common carotid artery, 3) the method of operation for the reconstruction of the common carotid artery and 4) Mata's test.

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As a procedure, 1-5mg heparin was injected into the mesenteric artery of the jejunal segment before the resection was carried out, and then we ligated and cut down the vessels at the injected parts.
Such method carried nothing of uneasiness for thrombose in the isolated segment, when the operation lasted over 2 hours. And we did not notice the trouble some canulixation and perfusion by the dextran or heparin sodium, which preserved from the damage of the vascular intima of the isolated segment. Such a method indicates the higher existence of the ganglionic nerve cells in the intestinal wall in its segment by histological studies, that is the pacemaker of the intestinal movement.

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This paper presents the results of a new operative procedure which were performed on 20 cases with chronic dacryocystitis to repaire the nasolarimal duct by transplanting the flap of bulbar conjunctiva,
The procedure is as follows. At first, the conjunctiva) flap is rolled up around the Nelaton's catheter and it would be inserted into the nasolacrimal duct, previously dilated with probe and by curetting, through the incised lacrimal sac, and then the wound of skin sewed together so as to fix the Nelaton's catheter, and also the end of the, catheter should be fixed on the brow tightly by plaster.
Under observation of 4 to 30 months after the operation, out of 20 cases, 13 cases (65%) were secured satisfactory result, 5 cases (25%) were improved but not sufficiently, and 2 cases (10%) were unsuccessful.
The findings of the unsuccessful cases were as follows. In one case, the following facts, resulted by serious trachoma, i. e, the wide spread cicatrix in nasolarimal duct and inelastic cicatrized conjunctiva, by which the Nelaton's catheter couldn't be wrapped up fully, were found. In another case, in spite of energetic antiphlogistic treatment, tenacious and continuous oppresive pain didn't subside, at last dacryocystectomy was carried out.

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Nissol is a new agricultural chemicals developed by Nippon Soda Co. Ltd, as a miticide. It is an organic flourine compound, chemically named N-Methyl-N-(1-naphthyl) fluoroacetamide with a following chemical formula.
I studied the antidotal virtue to Nissol intoxication on the living body and results was as follows:
1) From the hematological point of view I found a decrease of leucocytes in rabbits by Nissol injection. Some drugs, such as Sodii thiosulfate, Gluthrtione, Cystine, Paniltin, Mercapto, Thiola, Methionine, Antabuse, Thiourea, Vitamin B₁, Alinamin, Thioctic acid, Chlorpromazine, Vitamin B₆, Orotic acid, Vitamin C, Glucose, Glucuronic acid, Strong Neominophagen C, Glycyrrhizine, Acetamide and Monacetin are effective.
2) No significant differences were found in the blood-sugar level of the rabbit betweenn the Nissol injection and the control group.
3) There is a rectilinear relation between the survival time (t) and the Nissol concentration (C).
This data fits the Freundlich adsorption isotherm and this phenomenon is an adsorption as it applies to the Ostwald toxic equation.
4) Paramecium and Colibacillus are killed by concentrated Nissol.

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We had experienced a case of diffuse disseminated pancreato-lithiasis which manifested with severe sugar metabolic insufficiency.
The patient was 53 years old male with a history of laparotomy for an epigastric tumor in 1955.
After five years, in 1969, he was admitted to Atami National Hospital with chief complaints of nausea, anorexia, diarrhea, malnutrition and thirst. In this first hospitalization sugar metabolic insufficiency was well controlled by P. Z. I. and R. I. Proteinuria, hematuria and hypertension were not discovered, but he had diabetic retinopathy. Thereafter, he had been received insuline therapy in the out patient clinic.
In 1964 he was admitted to the hospital again with pyothorax. At this time the sugar metabolic insufficiency was aggravated, and the increase of blood pressure, neuralgic pain, proteinuria and hematuria were observed.
In the middle of May, 1965, he had a hypoglycemic episode, and in June he had to be hospitalized for hypertension, edema and diarrhea. In this 3rd hospitalization the control of diabetes by insuline was very difficult. He was suffered from the disturbance of speech and consciousness. Finaly he died on the 19th of July of heart failure caused by bronchopneumonia.
At autopsy pancreatic tissue was almost completely destroyed by fibrinization, and the numerous grayish white, irregular shaped, crenate stones were cramed in pancreatic ducts. But calcification of pancreatic tissue was not observed. In kidney typical pathological changes of diabetic glomerulonephritis were seen. Arteriosclerosis was noticed in aorta, coronal and cerebral arteries. Numerous micro softnings were separated in cerebral tissues. In right lung severe bronchopneumonia was seen.
The patient died of pancreatic insufficency with diffuse and disseminated calcification. The significance of this case is its wide distribution of pancreatic calcifications with progressive insular deficiency, and without remarkable failure in secreting funetinon of pancreas.

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A case of malignant lymphoma of 55 year-old man was reported.
We used the lymphography to notice the condition of retroperitoneal lymphnodes and traced sucessively the process of reduction of the lymphnodes by deep ⁶⁰Co therapy for 6 months.
The lymphography is a useful method without any serious side-action to observe the features of lymphatic system.

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