Abstract
Ten cases with wide-spread childhood malignancy were treated with chemotherapy. They were 3 cases of neuroblastoma, 2 cases of malignant lymphoma, a rhabdomyosarcoma, a dysgerminoma, an osteosarcoma, a Wilm's tumor and unclassified malignant tumor.
Combination chemotherapy of Vincristine 0.075mg/kg and Endoxan 10mg/kg was given to 4 cases: a patient with neuroblastoma had no response, a patient with neuroblastoma showed disappearance of the tumor cells in the bone marrow and decreased size of the abdominal tumor with radiation therapy, a patient with dysgerminoma revealed marked tumor regression and a patient with unclassified malignant tumor showed disappearance of tumor cells in the bone marrow and the tumor regression. Toxicity were one weakness of the muscles, two diminished knee jerks, two alopecias and three leukopenias.
Endoxan 25mg/kg wekly regimen was given to the patient with rhabdomyosarcoma and a good response was obtained and alopecia was noticed.
Endoxan 10mg/kg was administered to 2 cases intravenously in 9-13 consecutive days in three times: a patient with suspected neuroblastoma showed marked tumor regression in the thoracic cavity. In patient with multiple lung metastasis of osteogenic sarcoma, significant tumor regression occured twice. Toxic manifestation were nausea, vomiting and alopecia. The bone marrow depression was transient and recovery was rapid after cessation of therapy.
In combination chemotherapy of steroid and Endoxan to 2 patients with malignant lymphoma, one responded and one did not.
Triple therapy of Endoxan, Actinomycine-D and Methotrexate to dysgerminoma was failed. Side effect was mouth ulcer.
Actinomycine-D was given to 2 patients four times: a patient with metastatic dysgerminoma revealed transient tumor regression three times, and a patient with Wilm's tumor had no response.
