Abstract
In 624 hypertensive subjects whose clinical processes were able to be followed up during over five years, effect of long-term treatment with antihypertensive drugs on clinical and pathological states was observed and the cause of death was analysed. 624 hypertensive subjects were divided into three groups as follows: group I (302 cases) consisted of continuously consulting subjects, group II (256 cases) consisted of recently discoutinued subjects, and group III (66 cases) consisted of died subjects.
In group I, antihypertensive effect in the subjects administrating diuretics was significantly stronger than that in the subjects using non-diuretic agents.
Effect of long-term using of antihypertensive drugs on brain, heart and kidney in hypertensive subjects were observed. There were some cases indicating the improvement of Keith-Wagener's classification and therefore long-term using of antihypertensive drugs may protect the sclerosis of artery of brain. Long-term using of them was no effective on electrocardiographic findings, and as the cases with hypertensive heart disease were observed in only one per cent, so long-term using of them may protect the appearance of heart failure. In some cases in I group, urinary protein became negative and this fact may show that long-term treatment with antihypertensive drugs improves the function of kidney in hypertensive subjects.
Furthermore, long-term using of oral diuretics resulted hypokalemia, hyperglycemia and increased uric acid in blood.
In group II, it was found that the patients ranged from fifty years old to seventy years old were eager to administrate the antihypertensive drugs and thirty per cent of II group felt subjectively unwell.
In group III, causes of death in subjects with hypertension were researched and especially relationship between causes of death and pathological types (brain type, heart type and kidney type) were observed. Kidney death consisted kidney type in 100%, brain death consisted of brain type in 88% and heart death consisted of heart type in 61%, and so it was most difficult to forecast the cause of death in a case of heart death.
