抄録
Glycosiamine in urine of healthy men and tuberculous patients was determined under various conditions as during methionine treatment, during streptomycin therapy and during gelatin administration. The results of the study were as follows:
(1) In the case of healthy men, the excretion of glycosiamine is affected by the diet, especially by its albumen content.
(2) In the case of tuberculous patient the amount of glycosiamine excretion was found less as compared with healthy men. The severer the disease process the less the amount excreted.
(3) The glycosiamine excretion was found less during the methionine ingestion than that of without treatments as compared with the period in which no snch treatment was given.
(4) The glycosiamine excretion during methionine treatment is remakable in healthy men while it is less marked in tuberculous patient indicating a relationship of glycosiamine excretion and the severity of the disease process. In certain serious cases however, the glycosiamine excretion was increased on the first day after the methionine administration.
(5) A temporary increase of glycosiamine excretion is observed during streptomycin treatment. However, it showed a gradual decrease.
(6) Glycosiamine excretion is greater during streptmycin treatment in the slightly and moderately advanced cases while it is less in the serious cases.
(7) When gelatin is administered the excretion of glycosiamine is increased. While it is rapidly excreted by healthy men, it takes longer time in the tuberculous depending on the severity of the disease process.
(8) When gelatin is administered after methionine ingestion the glycosiamine excretion is found less as compared with no such treatment being given.
(9) Almost the similar result is obtained when gelatin is administered after the streptmycin therapy.
From above results we can conclude that the glycosiamine forming function and the function of converting glycosiamine to creatine are markedly decreased in tuberculous patients. It is probable that there might be a functional deficiency other than simple methionine deficiency since the creatie fo formation in the advanced tuberculous patients is not sogreat as in healthy men evenn when methionine is administered.
