マウスの記憶に及ぼすリドカインの影響（補遺）

マウス脳内アセチルコリン含量に及ぼすリドカインの影響

抄録

The present study examined the effects of lidocaine, a local anesthetic, on the central cholinergic system in mouse brain. The mice were killed 5,10,20 and 60 min after the intraperitoneal injection of a non-convulsive dose (40㎎/kg) or a convulsive dose (80㎎/㎏) of lidocaine. The acetylcholine (ACh) contents in the striatum, hippocampus, cerebral cortex and hypothalamus were measured by HPLC-ECD. The ACh contents in the striatum and hippocampus increased 60 min after the injection of the non-convulsive dose of lidocaine. Those in the cerebral cortex increased 20 and 60 min after the injection of the non-convulsive dose of lidocaine. On the other hand, the changes in ACh contents in the striatum, cerebral cortex and hypothalamus after the injection of the convulsive dose of lidocaine showed a time-dependent diphasic pattern: the ACh contents in these brain regions decreased 5 min after the injection of the convulsive dose of lidocaine, and increased 20-60 min after the injection. These findings suggest that lidocaine has an influence on the central cholinergic system.