The aim of this study was to evaluate the efficacy of collagen- or laminin-immobilized titanium implant on surrounding bone formation after implantation in a rat molar model. Collagen or laminin was immobilized onto titanium implants using a tresyl chloride-activated technique. The rat first molars were extracted and then the implants were immediately placed in the tooth sockets. At 4 weeks after implantation, undecalcified sections were prepared and bone response around the implants was evaluated. The value of bone to implant contact was significantly greater around the collagen-immobilized implants than around the titanium- and laminin-immobilized ones. It is assumed that immobilized collagen triggered bone formation around the implant material. These results suggest that collagen immobilization accelerates new bone formation.
