Journal of Oral Tissue Engineering
Online ISSN : 1880-0823
Print ISSN : 1348-9623
ISSN-L : 1348-9623
Hypergravity Effect on TRAP and Cathepsin K mRNA Expression in Cultured Osteoclasts
Atsuko NEMOTOToshimasa UEMURA
キーワード: Osteoclast, Gravity, TRAP, Cathepsin K
ジャーナル フリー

2004 年 2 巻 1 号 p. 31-34


Microgravity in space has been reported to enhance bone resorption in vitro and in vivo, however, the gravity effect on bone remodeling is not well understood. In particular, there are only a few reports about gravity effect on osteoclasts. In the present study, we examined the hypergravity effect on mRNA expressions of osteoclast marker enzymes such as TRAP (tartrate-resistant acid phosphatase) and cathepsin K. Osteoclasts were exposed to 30 x g for 2 hr or 18 hr. Results suggested that hypergravity enhanced the mRNA expression of both enzymes with different manner; the expression of the TRAP showed a slight increase, that of the cathepsin K showed a non-monotonous time course with maximum hypergravity effect for short time (2 hr) incubation.

© 2004 by Japanese Association of Regenerative Dentistry
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