2013 年 9 巻 p. 1-5
To study the effectiveness of two-dose measles vaccination, we examined the antibody titer in the serum of first graders before and after the introduction of the two-dose measles-rubella (MR) vaccination program.
A total of 826 first graders (553 boys and 273 girls) who entered school from 2004 to 2009 were studied. We compared the measles IgG antibody in the serum (enzyme immunoassay) and measles antibody positive rate before and after the introduction of the two-dose MR vaccination program in 2007.
The measles IgG antibody titer (4.9 ± 1.6) (M ± SD) and antibody positive rate (97.8%) after the introduction of the two-dose MR vaccination program were significantly higher than the values (3.3 ± 1.9 and 93.4%, respectively) recorded before its introduction.
We concluded that the implementation of two-dose measles vaccination for preschool children resulted in a significantly enhanced measles serum antibody titer among first graders. To eradicate measles, we recommend the two-dose MR vaccination.
