抄録
To elucidate the health problems caused by life in space, it is essential to understand the effect of microgravity on the molecular mechanisms of living cells. In our ground-based research using Xenopus A6 and A8 cell lines, suppression of ‘dome’ formation was observed in A6 cell line under simulated-microgravity conditions as compared to normal gravity conditions. Moreover, expression of various genes was affected by simulated-microgravity in A6 and A8 cell lines. These findings suggest that microgravity may affect cell morphology and gene expression during a space flight. Our studies will contribute significantly to the understanding of cellular responses and organ functions in space.
