抄録
The medium, in which macrophages were incubated with acetylated LDL (a-LDL) for 24 hours was collected. The medium was added to the medium in which rabbit aortic smooth muscle cells were incubated. The medium derived from the macrophages incubated with a-LDL remarkably enhanced the incorporation of 3H-cholesterol into smooth muscle cells and increased the content of total cholesterol in smooth muscle cells.
Above these results, it was suggested that the factor which was released from macrophages incubated with a-LDL might regulate the lipid metaholism in smooth muscle cells and might cause the formation of foam cell originated from smooth muscle cells.
