抄録
The phenotypes of human apoprotein E were studied in 91 normolipidemic persons using isoelectric focusing method. Observed phenotypes and their frequencies were E 3/3=72.5%, E 4/3=18.7% and E 3/2=8.3%. On this bases, gene frequencies were calculated: ε4=0.09; ε3=0.87; ε2=0.04. In comparison with those reported by Utermann and Zannis, the frequency of ε3 was significantly higher (p<0.01vs. Utermann and Zannis), and the frequency of ε2 was lower (p<0.05vs. Utermann, p<0.01vs. Zannis). This result was implied that there were racial differences in gene frequency of apoprotein E.
The mean levels of plasma cholesterol, triglyceride, HDL-cholesterol and apoproteins (A-I, B, E) were compared among phenotypes. The triglycerides concentration of phenotype E 3/2 was somewhat higher than others, but the difference was not statistically significant. No significant differences were found in the levels of cholesterol, HDL-cholesterol and apoproteins among phenotypes.
