実験的高脂血ウサギの微小循環動態ならびに副腎機能の変化に及ぼすビタミンEの影響

抄録

Changes in microcirculatory behaviors of blood cells and adrenal function during the process of atherogenesis were observed in rabbits fed a high cholesterol (CH) diet (1.5% w/w) with (+E group) or without (CH-group) vitamin E (100-150mg/day) for 12 weeks.
Vitamin E addition to the high-CH diet suppressed the increases in blood levels of CH, TG and A. I., and the abnormal microcirculatory changes. It also diminished the CH-deposition of aorta and the formation of decubital ulcer of paws.
Increases in corticoids (CS) were less and correlation of plasma CS with CH and A. I, were higher in +E group than CH group.
Adrenaline (A) and noradrenaline (NA) concentration in blood did not change throughout but in adrenals, their net contents was higher in +E group. Significant increase in NA in heart was observed and, with the increase of dopamine-β-hydroxydase, the acceleration of synthesis of catecholamines (CA) was demonstrated.
From the results obtained, it might be concluded that the administration of vitamine E promoted CS- and CA- actions and, then, accelerated fat metabolism and improved abnormal microcirculatory state in hyperlipidemic rabbits.