抄録
In order to know abnormalities of blood coagulation in atherosclerosis and diabetes mellitus, relationship between plasma fibrinogen as factor I of blood coagulation and atherosclerosis was studied. As a result, plasma fibrinogen was found to have higher level in atherosclerosis than normal. And significant increase of plasma fibrinogen was shown in diabetics with atherosclerotic vascular complication, hypertensive patients with ischemic ECG tracing and cerebral stroke. Plasma fibrinogen in cerebral haemorrhage was shown to be increasing as compared with cerebral infarction. Plasma fibrinogen remained high untill three weeks after myocardial infarction. But no change of serum lipids was observed after attack. Therefore plasma fibrinogen was significantly increased in patients who had clinical manifestations of atherosclerosis. Also there was a close relationship between increasing fibrinogen level and patient's clinical course. These patient's atheromatous lesions in arterial wall were suspected to be progressive. If hypercoagulable state induced by the increase of fibrinogen often occures in atherosclerotic patients, thrombus formation on the atheromatous lesions will be accelerated resulting in arterial vascular occulusion. Then, ischemia and necrosis occuring in the peripheral vital organ will contribute to form clinical manifestations as infarction, haemorrhage and stroke. Whenever estimation of the course and prognosis in atherosclerotic patients is made, the follow-up fibrinogen measurement seems to be more necessary than serum lipids measurements such as cholesterol. It can be concluded that the increase of plasma fibrinogen in patients with atherosclerosis shows to reflect clinical manifestations caused by “thrombus formation” on atheromatous lesions. And it was found that there was a reverse correlation between lipolytic activity and fibrinogen concentration in diabetics and atherosclerotic patients.
